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Page TITLE PAGE.i DECLARATION.ii DEDICATION.iii ACKNOWLEDGMENTS.iv TABLE OF CONTENTS.vi LIST OF TABLES.xiii LIST OF FIGURES.xviii ABRREVIATIONS.xx SUMMARY.xxii CHAPTER I .1 INTRODUCTION.1 CHAPTER II.5 REVIEW OF THE LITERATURE.5 2.1 ULCERATIVE DISEASES OF THE GENITAL TRACT OF SMALL RUMINANTS.5 2.1.1 Contagious pustular dermatitis.5 2.1.2 Ulcerative dermatosis.5 2.1.3 Sheath rot.6 vi.
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The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol CALCIFEDIOL ; . Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption. Date PubMed ID Outcome Statement BACKGROUND: Calcitriol and calcipotriol, two vitamin D derivatives, are available for topical treatment of psoriasis and have been shown to be effective . METHODS: This was a multicentre, randomized, investigator-masked, and parallel comparison in subjects with mild to moderate chronic plaque-type psoriasis receiving either calcitriol or calcipotriol ointment twice daily for 12 weeks Finally, these nonsecosteroidal VDRMs were less calcemic in vivo, and LY2108491 exhibited more than 270-fold improved therapeutic index over the naturally occurring VDR ligand 1, 25-dihydroxyvitamin D3 [1, 25- OH ; 2D3] in an in vivo preclinical surrogate model of psoriasis. Calcitriol and other vitamin D-analogues are effective in the treatment of psoriasis because of their anti-proliferative and pro-differentiation effects . One mechanism for UVB-light therapy in psoriasis could be the induction of calcitriol synthesis A left right comparison of twice-daily calcipotriol ointment and calcitriol ointment in patients with psoriasis: the effect on keratinocyte subpopulations Vitamin D3 analogues are a first-line treatment of chronic plaque psoriasis, but so far, comparative clinical studies on calcipotriol and calcitriol ointment are sparse, and in particular no comparative studies are available on cell biological effects of these compounds in vivo . For 8 weeks, 20 patients with psoriasis vulgaris were treated twice daily with calcipotriol and calcitriol ointment in a left right comparative study Calcitriol ointment and clobetasol propionate cream: a new regimen for the treatment of plaque psoriasis In this two-phase parallel-group study, the naturally occurring vitamin D3 analogue, calcitriol, was compared with the vitamin D analogue calcipotriol in 125 patients with chronic plaque-type psoriasis . At week 2 the investigator's global assessment showed clinical success psoriasis markedly improved, almost clear or clear ; for more than 50% of the patients in both groups and for 48 79% ; and 56 88% ; patients, respectively in the calcitriol and calcipotriol regimen group at week 12 . The present study shows that for the treatment of mild to moderate plaque psoriasis calcitriol 3 mug g ointment can provide a safe and effective alternative to calcipotriol 50 mug g ointment while being administered within a regimen based on a bitherapy with corticosteroids followed by a vitamin D3 maintenance monotherapy. Intra-individual comparison of the cutaneous safety and efficacy of calcitriol 3 microg g -1 ; ointment and calcipotriol 50 microg g -1 ; ointment on chronic plaque psoriasis localized in facial, hairline, retroauricular or flexural areas Several clinical trials have demonstrated that calcitriol, the naturally occurring and hormonally active form of vitamin D3, is effective and safe at the dose of 3 microg g -1 ; for the treatment of psoriasis affecting the trunk and limbs . METHODS: We compared the safety and efficacy of calcitriol 3 microg g -1 ; ointment and calcipotriol 50 microg g -1 ; ointment in a multicentre, randomized, investigator-blinded, left-right comparison in mild to moderate chronic plaque psoriasis affecting sensitive areas, defined as being the face, hairline, retroauricular and flexural areas . CONCLUSIONS: In the present study, calcitriol ointment was found to be better tolerated and would appear to be more effective than calcipotriol ointment in the treatment of psoriasis in sensitive areas. Calcitriol shows greater persistence of treatment effect than betamethasone dipropionate in topical psoriasis therapy RESULTS: Both treatments were efficacious; improvement in psoriasis or clearance of lesions residual erythema was allowed ; was recorded for 79% and 82% of patients receiving calcitriol or betamethasone dipropionate, respectively . CONCLUSION: Twice-daily applications of either calcitriol 3 microg g ointment or betamethasone dipropionate 0.05% ointment can be used to good effect in the treatment of chronic plaque psoriasis Calcium homeostasis remains unaffected after 12 weeks' therapy with calcitriol 3 microg g ointment; no correlation with extent of psoriasis OBJECTIVE: To assess the systemic safety of calcitriol 3 microg g ointment Silkis ; ointment ; in relation to body surface area BSA ; affected by chronic plaque psoriasis . No changes in calcium or phosphate homeostasis related to the area of psoriasis being treated with calcitriol ointment were detected . CONCLUSIONS: Reductions in the global severity score and BSA involvement, as well as results of the assessment of improvement, attested to the clinical efficacy of calcitriol 3 microg g ointment in psoriasis A new topical formulation of calcitriol 3 microg g ointment ; has been shown to be effective in the treatment of stable plaque-type psoriasis . These studies showed that calcitriol 3 microg g ointment is a well-tolerated treatment for stable plaque-type psoriasis. Efficacy and tolerance of topical calcitriol 3 microg g -1 ; in psoriasis treatment: a review of our experience in Poland These results suggest that calcitriol 3 microg g -1 ; ointment is an effective and safe treatment for chronic plaque psoriasis. Clinical experience with topical calcitriol 1, 25-dihydroxyvitamin D3 ; in psoriasis Finally, two studies confirm that calcitriol 3 microg g -1 ; ointment can be used safely in patients with psoriasis of the head and confirm the high level of clinical efficacy achieved with this compound. Calcitriol 3 microg g -1 ; ointment Silkis ointment, Galderma Laboratories ; is a new treatment for psoriasis . This paper summarizes the findings of the preclinical and early clinical studies that provided the foundation of the later Phase II and III clinical trials on efficacy and safety with topical calcitriol 3 microg g -1 ; ointment for the treatment of plaque psoriasis. Calcitriol 3 microg g-1 ointment in combination with ultraviolet B phototherapy for the treatment of plaque psoriasis: results of a comparative study OBJECTIVES: To determine the efficacy of calcitriol 3 microg g-1 ointment in combination with UVB phototherapy Apr 2007 17373972.
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